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DG DISPATCH - APSS: Restless Leg Syndrome Associated With Many Disorders By Jill Stein Special to DG News LAS VEGAS, NV -- June 20, 2000 -- Researchers have found that patients with restless legs syndrome (RLS) are much more likely to have been previously diagnosed with extrapyramidal disorders, musculoskeletal disorders, depression, and joint and back disorders than patients without RLS. Researchers at the University of Manitoba used the Province of Manitoba Health database to compare the diagnoses made in the five years before sleep laboratory evaluation of 218 patients with RLS (103 men and 115 women) and 872 matched control subjects from the general population. Meir Kryger, MD, presented the findings of the study at the 14th Annual Meeting of the Associated Professional Sleep Societies, in Las Vegas, NV. For several years before the RLS diagnosis was established, the patients in this study were diagnosed as having various disorders more frequently than controls, Dr. Kryger reported. Overall, 43.7 percent of men with RLS compared with 10.4 percent of men in the control group and 46.1 percent of women with RLS versus 22.8 percent of women in the control group had been diagnosed as having psychological/psychiatric disorders (most often depression). Extrapyramidal disease or movement disorders were previously diagnosed in 17.5 percent of men with RLS compared with 0.2 percent of their controls and in 23.5 percent of women with RLS versus 0.2 percent of their controls. Many patients had been previously diagnosed with disorders of the musculoskeletal system. Specifically, 35.9 percent of men with RLS versus 22.8 percent of their controls and 49.6 percent of women with RLS versus 23.3 percent of their controls had been diagnosed as having diseases of the joints. Disorders of the back were also more frequently diagnosed in RLS patients -- 21.4 percent of men with RLS compared with 13.1 percent of their controls and 38.3 percent of women with RLS versus 15.0 percent of their controls. Dr. Kryger said the data suggest that RLS may have a variety of causes and underscore the need for more detailed assessment of sleep in the management of such conditions as extrapyramidal disorders, musculoskeletal disorders, depression, and painful conditions such as joint and back disorders. Restless legs syndrome is characterized by disagreeable sensations in the legs that occur at rest and are relieved by movement. These symptoms, which are typically worse at night, may result in sleep onset or sleep maintenance insomnia. Most patients are found on polysomnography to have periodic limb movements during sleep. The disorder is usually idiopathic. E-mail this page to a friend or colleague! To print, use this version