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DG DISPATCH - ADA: Sildenafil Effective For Type 1 And 2 Diabetes By Jill Stein Special to DG News SAN ANTONIO, TX -- June 11, 2000 -- Oral sildenafil is an effective and reliable treatment for patients with erectile dysfunction (ED) who also have either type 1 or 2 diabetes, according to data presented at the 60th Scientific Sessions of the American Diabetes Association. Lawrence J. Blonde, MD, and co-workers at the Ochsner Clinic in New Orleans, LA, analyzed data from 11 randomized, double-blind, placebo-controlled trials of sildenafil for the treatment of ED ranging from 12 weeks to six months duration. In all the studies, patients were randomized to receive a starting dose of 50 mg of sildenafil or matching placebo that could be adjusted to 25 mg or 100 mg based on efficacy and tolerability. Subjects were instructed to take the study drug approximately one hour before sexual activity but not more than once daily. The trial included male outpatients, 18 years of age or older, in whom ED had been diagnosed at least six months earlier and who were in a stable relationship with a female partner for at least six months. Patients completed the International Index of Erectile Function (IIEF), a fully validated sexual function questionnaire that included questions on the ability to achieve and maintain an erection. At the end of treatment, patients were asked whether or not treatment had improved their erections. Patients receiving sildenafil reported significant improvement in their ability to achieve and maintain an erection compared with those who received placebo, Dr. Blonde reported. Treatment responses were lower for diabetic patients compared with nondiabetic patients but higher than previously reported. Sildenafil treatment for men with type 1 diabetes was associated with significant improvement in erectile function, with efficacy similar to that observed for men with type 2 diabetes. The prevalence of complete ED among men in the general population increases with age, from five percent among men aged 40 years to 15 percent among men aged 70 years, Dr. Blonde said. Erectile dysfunction is a common complication in men with diabetes. It frequently occurs at an earlier age in men with diabetes and is often associated with diabetic neuropathy and peripheral vascular disease. Several studies have shown a high prevalence of ED - from 35 to 75 percent - among diabetic men. Related Link: sildenafil (Viagra). E-mail this page to a friend or colleague! To print, use this version