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| | | ![]() DG DISPATCH - APA: Paroxetine Effective Against Hot Flushes in Survivors of Breast Cancer By Lara Pullen Special to DG News CHICAGO, IL -- May 19, 2000 -- A recent paroxetine study demonstrated substantial reduction in hot flushes and improvement in menopausal symptoms among breast cancer survivors. At the 2000 Annual Meeting of the American Psychiatric Association, in Chicago, IL, Kate Beebe, MD, of SmithKline Beecham Pharmaceuticals, presented the results of a five-week, open-label trial designed to evaluate changes in mood, anxiety, sleep, sexual function, and overall quality of life in perimenopausal with paroxetine. The study included 27 women over the age of 18 who had a history of breast cancer. The patients had a minimum of 14 hot flushes per week over at least one month. Patients undergoing cytotoxic chemotherapy, hormonal therapy other than tamoxifen, antidepressants, or other therapies for hot flushes (except for Vitamin E) were excluded from the study. The study found a 67 percent mean reduction in hot flushes. Of the 27 women, 67 percent responded with a greater than 50 percent reduction in the daily number of hot flushes (the typical placebo response is 27 percent). Patients treated with paroxetine experienced a significant improvement in overall quality of life and paroxetine was generally well tolerated. More than 80 percent of enrolled women chose to continue treatment at study conclusion. Related links: Paroxetine.
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