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DG DISPATCH - APA: Vagus Nerve Stimulation for Treatment-Resistant Depression By Lara Pullen Special to DG News CHICAGO, IL -- May 18, 2000 -- Long-term vagus nerve stimulation (VNS) appears to be a safe and effective treatment for a significant number of patients with severe, treatment-resistant depression. VNS stimulation is an approved form of therapy for treatment-resistant epilepsy and requires surgery and the "wearing" of a palm-sized stimulator. At the 2000 Annual Meeting of the American Psychiatric Association, in Chicago, IL, Lauren B. Marangell, MD, of Baylor College of Medicine, Houston, TX, presented the results of an open trial of the effects of VNS on depression. The trial included 30 outpatients with non-psychotic, major depressive disorder (n=21), bipolar I disorder (n=4), or bipolar II depressed phase disorder (n=5). These patients were in a current major depressive episode for two years or more or had four or more major depressive episodes in their lifetime. Patients in the study were allowed to take stable psychotropic medication regimens. There were 11 acute phase responders, of whom 91 percent maintained response at nine months. There were 16 acute phase non-responders, of whom 38 percent were responders by nine months. Data for the nine-month visit were not available for one acute phase responder and two acute phase non-responders. Any physicians interested in participating in the extension of the pilot study should phone the Physician Referral Line at 1-888-748-1657. E-mail this page to a friend or colleague! To print, use this version