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DG DISPATCH - APA: Depression Linked to Perimenopause By Lara Pullen Special to DG News CHICAGO, IL -- May 16, 2000 -- After controlling for past depression, perimenopausal women are 2.5 times more likely to have significant depressive symptoms than are aged-matched pre- and postmenopausal women. At the 2000 Annual Meeting of the American Psychiatric Association, Hadine Joffe, MD, of Harvard Medical School, Cambridge, MA, reported the results of a self-administered questionnaire that was given during a six-month period to all women entering women's primary care clinic for treatment. The study included 588 women, 29 percent of whom fell in the target age range (40-60 years). Approximately one-third of these women were premenopausal, one-third were perimenopausal and one-third were postmenopausal. The mean age was 48 years, and most women were married and caucasian. The questionnaire found that 7.4 percent of the premenopausal women were significantly depressed compared to 14.5 percent for perimenopausal women and 13.6 percent for postmenopausal women. The data show that women who are perimenopausal and have hot flashes seem to be at an increased risk for depression. Hot flashes increased the risk of depressive symptoms in perimenopausal women 4.6-fold. Past depression increased the risk of depressive symptoms in perimenopausal women 3.4 fold. "The data argue in favor of an estrogen withdrawal phenomenon," Dr. Joffe concluded. E-mail this page to a friend or colleague! To print, use this version