Unregistered User If this is not your name, click here.
		Contact Us | Order Now | Journals | Bookstore | Register a colleague
	Select a ChannelAcneAIDS and HIVAllergy OtherAlzheimer'sAnaesthesiology OtherAngina Pectoris/MIAnxietyArthritis OtherAsthmaBack PainBacterial InfectionsBladder CancerBone Marrow TransplantationBreast CancerCardiology OtherCataractCell TransplantationCervical CancerCholesterol/Lipid disordersCirrhosisClinical PharmacologyColorectal CancerCongestive Heart FailureContact DermatitisContraceptionCOPDCystic FibrosisDental and Oral DisordersDepressionDermatology OtherDiabetesDialysisEating DisordersElbowEmergency MedicineEndocrinology OtherEpilepsyErectile DysfunctionFibromyalgiaGastro OtherGeneticsGenitourinary OtherGeriatricsGERD/GastritisGlaucomaH. Pylori/UlcerHaematology OtherHair LossHeadachesHepa/Biliary OtherHepatitisHipHRTHypertensionIBDImmunologyInfectious OtherInfertilityIntensive CareIrritable Bowel SyndromeKneeLeukemiasLiver CancerLung CancerLupusLymphomasMelanomaMenopauseMultiple Sclerosis Nephrology OtherNeurologic OtherNutritional / Metabolic OtherOb/Gyn OtherObesityOncology OtherOphth. OtherOphthalmic SurgeryOrgan TransplantationOrthopaedics OtherOsteoarthritisOsteoporosisOtitisOtorhino. OtherOvarian CancerPaediatricsPainPancreatic CancerParkinson'sPregnancyProstate CancerPsychiatry OtherPulmonary OtherRadiologyRenal CancerRenal FailureRespiratory InfectionsRheumatoid arthritisRheumatology OtherRhinitisSchizophreniaShoulderSleep ApnoeaSleep DisordersSpineStrokeSTDsSurgeryThyroid DisordersTransfusionTransplant Surgery OtherTraumaUrinary IncontinenceUrinary tract infectionsVaccinologyVascular DisordersViral Infections

SEARCH   News Bookstore Medline The Web Meetings & Congresses Complete Doctor's Guide    EXPLORE :    All News   All Webcasts   All Cases   All Meetings & Congresses   All Medical Resources New drugs / indications English Dictionary Medical Dictionary Thesaurus Warning | Privacy | Awards  Favourite Journals  Click here to choose your favourite journals  Favourite Sites  Click here to choose your favourite sites  Languages  Select languageEnglishFrançais

ENDO: Bone Resorption Extremely Sensitive To Low Estradiol Levels In Anorexia Nervosa By Amy Lazarus Yaroch Special to DG News DENVER, CO -- June 24, 2001 -- Very low concentrations of serum estradiol are needed to improve catabolic bone metabolism in patients with anorexia nervosa. Dr. Mari Hotta with Tokyo Women’s Medical University, Japan, reported findings yesterday (June 23) at the 83rd Annual Meeting of the Endocrine Society (ENDO) in Denver, Colorado. Estrogen deficiency, which is the main symptom of anorexia nervosa, is characterized by bone resorption, decrease in bone formation, and subsequent osteoporosis, and is a serious threat to patients with the condition, according to researchers. They studied 62 Japanese women with amenorrhea, age 18-34 years with body mass indices (BMI’s) ranging from 9.6 - 22.8 kg/m2. Using a very sensitive assay, they measured levels of serum estradiol in these patients. “Serum estradiol levels decreased to less than 10 pg/mL in 29 patients and were undetected in five patients, researchers explain. Serum estradiol levels were positively correlated with BMI (r = 0.77, P < 0.0001). "Only a very low concentration of serum estradiol (1.36 - 3 pg/mL) is needed for inhibiting bone resorption and improving bone metabolism," Dr. Hotta told Doctor’s Guide. "The estradiol level sufficient for normalization of bone metabolism lies between 7 and 9 pg/mL." These findings have important implications for estrogen replacement therapy in patients with anorexia nervosa. Dr. Hotta advised Doctor’s Guide, "Physicians should try to use very low doses of estrogen in treating severely emaciated anorexia nervosa patients." E-mail this page to a friend or colleague! To print, use this version