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EULAR: Anakinra Helps Improve Functional Status In Some Rheumatoid Arthritis Patients By Thomas Buckingham PRAGUE, CZECH REPUBLIC -- June 15, 2001 -- Treatment with anakinra for rheumatoid arthritis (RA) lead to significant improvements in functional status compared to placebo, according to a study. Prof. P. Emery, from the Rheumatology and Rehabilitation Research Unit, University of Leeds, Leeds, England, presented these findings at the European League Against Rheumatism (EULAR) Congress, Prague, Czech Republic, held June 13-16. The study presented today was a 24-week, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of anakinra conducted in Europe in 473 patients. The goal of this study was to evaluate the effect of anakinra on the functional status of subjects with rheumatoid arthritis who were not using disease modifying anti-rheumatic drugs (DMARDs). For study entry, patients were required to have active RA using ACR criteria and could not have taken methotrexate, penicillamine, hydroxychloroquine, gold, azathioprine, or sulfasalazine within the past six weeks or cyclosporine in the past 24 weeks. 473 subjects received either one of three doses of anakinra (30 mg, 75 mg, or 150 mg) or placebo SC QD. Functional status was measured by the HAQ, which was administered at baseline and at weeks 12 and 24. The mean change in HAQ score was compared between subjects receiving anakinra (all doses) and those on placebo. Functional status improved for subjects on anakinra as their mean Health Assessment Questionnaire (HAQ) scores decreased by an average of 0.24 (p < 0.0003). This result was true for each dose of anakinra, as compared to placebo (data not shown). In summary, patients with RA not receiving DMARD who were treated with anakinra experienced statistically significant improvements in their functional status compared to subjects on placebo. These improvements were clinically significant. SOURCE: PeerView Press E-mail this page to a friend or colleague! To print, use this version