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ATS: Increase In Gastric Emptying Linked To Obstructive Sleep Apnea Syndrome By Guenther Krueger Special to DG News SAN FRANCISCO, CA -- May 24, 2001 -- Patients with obstructive sleep apnea syndrome may be experiencing prolonged gastric emptying of fluids, researchers reported yesterday at the American Thoracic Society meeting here. Dr. E. Almus of the Department of Internal Medicine at University Hospital Bergmannsheil in Bochum, Germany, reported on a study in which gastric emptying time was compared in patients with obstructive sleep apnea syndrome (OSAS) and matched healthy controls. Gastric emptying time is important not only for the development of oral therapy for OSAS but also to determine gastroesophageal reflux (GER)-delayed gastric emptying as a potential factor in the pathogenesis of the disorder. The association OSAS and GER is fairly common. Dr. Almus said, "A third of patients with sleep apnea have gastric reflux." He added that some studies give even higher percentages. How and why this happens is poorly understood and has not been examined closely in spite of the fact that the role of gastric emptying for the pathogenesis of GER disease has been shown to be important in other populations. In his study, 45 patients with polysomnographically confirmed OSAS were matched with 46 healthy volunteers. Gastric emptying of 300 mL of water at 17 degrees Celsius was measured by ultrasound antrumplanimetry in the aortomesenterial level. The area of the antrum was determined every three minutes as the mean from three single measurements. Other parameters were also used in order to increase precision. Age and body mass index were factored into the analysis. While there was no correlation between these variables in terms of the outcome, there was prolonged gastric emptying in the OSAS group. It was also noted that empty stomach area was increased in this group as compared to healthy subjects. Significant differences in terms of autoregulation, however, could not be demonstrated. Dr. Almus stated that this study is a precursor to further investigations that will look at how treatment affects the same process, i.e. whether there is an effect on gastric emptying time and/or a change in the prevalence of the GER. E-mail this page to a friend or colleague! To print, use this version