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APA: Seroquel (Quetiapine Fumarate) Effective in Reducing Anxiety in Schizophrenia NEW ORLEANS, LA -- May 9, 2001 -- Data being presented today at the American Psychiatric Association annual meeting suggest the atypical antipsychotic Seroquel® (quetiapine fumarate) Tablets, a product of AstraZeneca, is effective in reducing anxiety in patients with schizophrenia compared to haloperidol and placebo (1). Seroquel, a first-line atypical antipsychotic, is indicated for the treatment of schizophrenia. "Anxiety complicates the management of schizophrenia and makes treatment more difficult," said author Dr. Andrew J. Cutler, president, Coordinated Research of Florida, Inc. and Clinical Assistant Professor, Department of Psychiatry and Behavioral Medicine, University of South Florida. "These results suggest that Seroquel is effective in reducing anxiety, therefore helping patients with schizophrenia recover more effectively and live more normal lives." A meta-analysis was conducted to examine data from three placebo-controlled (n = 422) and four haloperidol-controlled (n = 723) six-week trials (12 weeks for one of the trials) in patients suffering from schizophrenia (1). The men and women, ranging in age from 18 to 75 years, were hospitalized with severe symptoms of schizophrenia. Researchers pooled the data from the seven studies and measured levels of improvement with the Brief Psychiatric Rating Scale (BPRS) anxiety item and BPRS Factor I, a combined measure of somatic concern (preoccupation with physical health and fear of physical illness), anxiety, guilt feelings and depression (1). Results of this meta-analysis showed that Seroquel, up to 750 mg/day, produced significantly greater reductions in anxiety compared with placebo (-0.70 vs -0.16) or haloperidol, up to 20 mg/day, (-0.56 vs -0.39) as measured by mean changes from baseline in BPRS individual item of anxiety (1). Seroquel also produced significantly greater reductions in BPRS Factor I scores compared with both placebo (-0.59 vs -0.29) and haloperidol (-0.48 vs -0.34) (1). References: (1) Cutler, Andrew J. Quetiapine, Evidence in reducing Anxiety: Clinical Evidence. Poster presented at the APA, May 2001. SOURCE: AstraZeneca Related Links: Seroquel (quetiapine fumarate) and AstraZeneca. E-mail this page to a friend or colleague! To print, use this version