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DG DISPATCH - AAD: Topically Applied Soy May Benefit Acne By Maggie Schwarz Special to DG News WASHINGTON, DC -- March 5, 2001 --The healthful benefits of soy may not be limited to the soy foods that can be incorporated into diets. Topically applied soy may improve acne. At the American Academy of Dermatology’s annual meeting here, R.M. Grossman, MD, and colleagues from Johnson & Johnson reported on a clinical trial evaluating potential of a soy formulation to improve redness and acne in 26 women with mild acne and 29 women without acne. Sixty-four percent of the women were Caucasian, 36 percent African-American. The women applied the soy formulation twice daily and were evaluated after three, seven, 14, 21, 28, and 35 days. In acne patients, inflammatory pimples diminished significantly from baseline (p<.001). There was also a significant decrease in moderate redness at Days 28 and 35 (p=.002). Non-inflammatory blackheads trended toward reduction. No significant cutaneous irritation (erythema, peeling, dryness and burning/stinging) resulted from applying the formulation. Soy is composed of several ingredients, including small soy proteins such as soybean trypsin inhibitor and Bowman-Birk inhibitor, as well as isoflavones. The latter are a class of phytoestrogens found primarily in soybeans. Other components include carbohydrates, lipids, phospholipids and saponins. Though small in scale and open-label, in this study, soy-containing moisturizer reduced the number of inflammatory pimples significantly in patients with mild acne. Moderate erythema decreased significantly after four weeks. A formulation of moisturizer containing soy holds promise as a valuable cosmetic skin care option for those with acne-prone skin, the researchers concluded. E-mail this page to a friend or colleague! To print, use this version