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DG DISPATCH - TLLC: Rituximab Promising In Relapsed Non-Hodgkin’s Lymphoma After Autologous Stem-Cell Transplantation By Margaret Pearson Special to DG News NEW YORK, NY -- July 18, 2000 -- Rituximad can be used in patients with relapsed non-Hodgkin’s lymphoma who have been previously treated with autologous bone marrow transplantation, research suggests. Physicians, headed by N. Miranda, MD, of the Instituto Portugues de Oncologia, in Lisbon, reported on their findings about rituximab at the 13th International Symposium on the Treatment of Lymphoma, Leukemia, and Cancer in New York. Rituximab, a monoclonal antibody (anti-CD20), has been shown to be effective in relapsed low-grade non-Hodgkin’s lymphoma (NHL). In more aggressive lymphomas and in relapses after high-dose chemotherapy, encouraging results -- with either isolated rituximab treatment or in combination with other chemotherapy -- have been reported. The researchers presented their experience with three relapsed NHL patients treated with rituximab who underwent autologous bone marrow transplantation (BMT). Since 1998, they treated three patients. One of these had follicular NHL and was 59 years if age, was four months post-autologous bone marrow transplant (ABMT) and was alive and well for more than 354 days. Another patient had diffuse large-cell B NHL, was 39 years of age and one month post-ABMT and died of progressive disease. The third patient had mantel cell lymphoma, was 45 years of age, was one year post-ABMT and relapsed after 130 days. The only side-effect was fever and one patient complained of painful lymph node swelling. One of the patients had a refractory lymphoma and died three months after rituximab treatment. One had a complete clinical response after rituximab that lasted four months and is currently undergoing chemotherapy. The doctors concluded that rituximab is a low toxicity treatment which is feasible in relapses after high-dose chemotherapy. They added that its precise clinical role in relapsed NHL after autologous bone marrow transplant remains to be established by further studies. E-mail this page to a friend or colleague! To print, use this version