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DG DISPATCH - TLLC: New Treatment Strategies Available For Hodgkin’s Disease And Non-Hodgkin’s Lymphoma By Margaret Pearson Special to DG News NEW YORK, NY -- July 17, 2000 -- New and upcoming treatment strategies for Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL) were presented by Dr. Anas Younes of the M.D. Anderson Cancer Center, Houston, TX, at the 13th International Symposium on the Treatment of Lymphoma, Leukemia, and Cancer in New York. Recently, several new agents have been tested in patients with HD and NHL. Some of these agents have been FDA approved and have already been incorporated into treatment of newly diagnosed patients. In those patients with relapsed aggressive NHL, paclitaxel and topotecan have shown promising effects. Monoclonal antibodies (naked and radioimmune conjugated) alone or in combination with chemotherapy have already been reported to achieve high response rates in patients with indolent, aggressive and mantle cell NHL. Rituximab, which is an unconjugated anti-CD20 monoclonal antibody, achieves a 30 to 50 percent response rate in various types of relapsed B-cell lymphoma. Based on its good response rate and minimal toxic effect, many investigators have combined rituximab with chemotherapy to treat newly diagnosed NHL. Iodine and yttrium conjugated anti-CD20 antibodies are also currently being evaluated with promising results. Also showing good early results in patients with relapsed cutaneous T-cell lymphoma is interleukin 12 (IL12), which is currently being evaluated for relapsing NHL and HD. More recently, independent investigators have demonstrated that CD40 ligand can enhance the survival of malignant B lymphocytes, and may mediate their resistance to chemotherapy. The therapeutic interruption of this pathway may be of clinical value. Tumor necrosis factor receptor apoptosis-inducing ligand (TRAIL), preferentially kills tumor cells while sparing normal cells. Therefore, TRAIL seems to be a promising novel treatment for cancer. E-mail this page to a friend or colleague! To print, use this version