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DG DISPATCH - AIDS 2000: Abacavir-containing Triple Nucleoside Analogue Therapy Better Than AZT/3TC Alone By Ed Susman Special to DG News DURBAN, SOUTH AFRICA -- July 14, 2000 -- The combination of three nucleoside analogues -- abacavir and AZT/3TC -- showed similar, if not better effectiveness in reducing viral load than a protease inhibitor combination, indinavir and AZT/3TC. In a open-label, multi-center study of 342 antiretroviral therapy-naive patients, patients were randomized to receive either combination for 48 weeks. At 24-weeks, in an intent to treat analysis, 68 percent of 164 patients on the three nucleosides had suppressed virus below the 400 copies/ml assay limit, compared to 57 percent of the 166 patients on the indinavir-containing regimen. In addition, analysis of the data indicated that 74 percent of 145 subjects on the nucleosides versus 45 percent of 146 patients on protease regimen reported taking all antiretroviral doses over the previous four weeks or missed less than one dose per week. Pedro Cahn, MD, of the Huesped Foundation of Buenos Aires, who presented the data at the XIII International AIDS Conference, in Durban, South Africa, said, "The results show there was a tendency toward better adherence in the abacavir arm of the study." He said that only about 25 percent of patients taking the protease inhibitor took all the doses of the medication, compared with 56 percent of patients taking abacavir. Dr. Cahn said there were more adverse events in the protease arm (75 percent) compared with 59 percent of those taking the triple nucleoside regimen. "In this preliminary analysis of the open label comparison," Dr. Cahn said, "the triple nucleoside combination was similar in antiretroviral effect to the protease combination, regardless of the screening viral load." He said CD4 cell increases were also similar for the two arms of the study, which will continue for another 24 weeks. E-mail this page to a friend or colleague! To print, use this version