Unregistered User If this is not your name, click here.
		Contact Us | Order Now | Journals | Bookstore | Register a colleague
	Select a ChannelAcneAIDS and HIVAllergy OtherAlzheimer'sAnaesthesiology OtherAngina Pectoris/MIAnxietyArthritis OtherAsthmaBack PainBacterial InfectionsBladder CancerBone Marrow TransplantationBreast CancerCardiology OtherCataractCell TransplantationCervical CancerCholesterol/Lipid disordersCirrhosisClinical PharmacologyColorectal CancerCongestive Heart FailureContact DermatitisContraceptionCOPDCystic FibrosisDental and Oral DisordersDepressionDermatology OtherDiabetesDialysisEating DisordersElbowEmergency MedicineEndocrinology OtherEpilepsyErectile DysfunctionFibromyalgiaGastro OtherGeneticsGenitourinary OtherGeriatricsGERD/GastritisGlaucomaH. Pylori/UlcerHaematology OtherHair LossHeadachesHepa/Biliary OtherHepatitisHipHRTHypertensionIBDImmunologyInfectious OtherInfertilityIntensive CareIrritable Bowel SyndromeKneeLeukemiasLiver CancerLung CancerLupusLymphomasMelanomaMenopauseMultiple Sclerosis Nephrology OtherNeurologic OtherNutritional / Metabolic OtherOb/Gyn OtherObesityOncology OtherOphth. OtherOphthalmic SurgeryOrgan TransplantationOrthopaedics OtherOsteoarthritisOsteoporosisOtitisOtorhino. OtherOvarian CancerPaediatricsPainPancreatic CancerParkinson'sPregnancyProstate CancerPsychiatry OtherPulmonary OtherRadiologyRenal CancerRenal FailureRespiratory InfectionsRheumatoid arthritisRheumatology OtherRhinitisSchizophreniaShoulderSleep ApnoeaSleep DisordersSpineStrokeSTDsSurgeryThyroid DisordersTransfusionTransplant Surgery OtherTraumaUrinary IncontinenceUrinary tract infectionsVaccinologyVascular DisordersViral Infections

SEARCH   News Bookstore Medline The Web Meetings & Congresses Complete Doctor's Guide    EXPLORE :    All News   All Webcasts   All Cases   All Meetings & Congresses   All Medical Resources New drugs / indications English Dictionary Medical Dictionary Thesaurus Warning | Privacy | Awards  Favourite Journals  Click here to choose your favourite journals  Favourite Sites  Click here to choose your favourite sites  Languages  Select languageEnglishFrançais

DG DISPATCH - APSS: Switch To Modafinil Benefits Patients With Narcolepsy By Jill Stein Special to DG News LAS VEGAS, NV -- June 20, 2000 -- New findings indicate that the wake-promoting agent modafinil significantly improves symptoms of excessive daytime sleepiness (EDS) in patients with narcolepsy who do not respond to treatment with central nervous system (CNS) stimulants commonly used to treat EDS. The results were presented at the 14th Annual Meeting of the Associated Professional Societies by Dr. Jonathan Schwartz, of Integris Southwest and Baptist Medical Centers in Oklahoma City, OK. The trial included 151 patients with narcolepsy, 18 to 65 years of age, who had been unsatisfactorily treated for EDS with dextroamphetamine, methylphenidate or pemoline. Prior treatment was considered unsatisfactory because of low tolerability, tolerance, abuse, dependence, patient dissatisfaction or the need for a drug holiday. After a two-week washout period, all patients received once daily modafinil, 200 mg, for one week. At the beginning of week 2, the investigator could increase the modafinil dose to 400 mg per day. During weeks 3 though 6, patients received their optimal dose of modafinil (either 200 mg or 400 mg per day). Efficacy was assessed by the Epworth Sleepiness Scale (ESS) at baseline and at weeks 1, 2, and 6. Approximately 70 percent of the patients were taking 400 mg modafinil daily, and 21 percent were taking 200 mg modafinil daily during weeks two through six, Dr. Schwartz said. The mean ESS scores were significantly improved from baseline as early as week 1 and improvements in EDS were maintained throughout the study regardless of the stimulant previously received. After six weeks of treatment with modafinil, 79 percent of the patients were rated by the investigators as clinically improved and 62 percent were rated as "much improved" or "very much improved." Results also showed that modafinil treatment was well tolerated. Related Link: modafinil (Provigil). E-mail this page to a friend or colleague! To print, use this version