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DG DISPATCH - APA: Fluoxetine Safe and Effective For Panic Disorder Symptoms By Lara Pullen Special to DG News CHICAGO, IL -- May 17, 2000 -- Fluoxetine (20 mg/day) is safe and well tolerated and appears to effectively reduce symptoms of panic disorder (including panic attacks). Dr. David Michelson of Eli Lilly and Company, in Indianapolis, IN, presented the results of a study at the 2000 Annual Meeting of the American Psychiatric Association, in Chicago, IL. The study was designed to expand upon the understanding of the efficacy of fluoxetine in patients having at least two full panic attacks during a two-week evaluation. In the multicenter, European study, patients meeting the Diagnostic and Statistical Manual (DSM)-IV criteria for panic disorder were randomized to fluoxetine (n = 90) or placebo (n = 90) and evaluated biweekly for 12 weeks. Fluoxetine was initiated at 10 mg/day during the first week and was increased to 20-60 mg/day thereafter. The protocol-defined primary outcome measure was the percentage of panic-free patients in the final visit interval at endpoint. A statistically significant greater number of patients were panic-free at six weeks and at the final visit when treated with fluoxetine. Fluoxetine-treated patients also reported a 50 percent or greater reduction in full panic frequency compared with placebo at six weeks and at endpoint. The researchers found, however, that the mean reduction in panic attacks measured by diary was not statistically different between the groups at either six weeks or endpoint. E-mail this page to a friend or colleague! To print, use this version