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DG DISPATCH - ICMASC: Clarithromycin Effective In Chronic Inflammatory Sinusitis By Jill Stein Special to DG News SEVILLE, SPAIN -- January 27, 2000-- A short course of therapy with the macrolide antibiotic clarithromycin can effectively control the signs and symptoms of stable chronic, inflammatory sinusitis in patients with no evidence of an acute infection. These findings were the results of a phase IV, open-label trial presented at the 5th International Conference on the Macrolides, Azalides, Streptogramins, Ketolides, and Oxazolidinones (ICMASC). The investigation followed 25 patients with clinically symptomatic, but stable, chronic sinusitis and persistent maxillary sinus inflammation - as demonstrated by a computed tomographic scan and mucosal biopsy - who were treated for 14 days with clarithromycin, 500 mg, twice daily. Patients were evaluated for their clinical status during five study visits: on a screening visit, on the first treatment day, and one day, one week and two weeks after the completion of treatment. The efficacy variables for the study included the clinical signs and symptoms as reported by the patients. A statistically significant improvement was observed over the 28-day treatment period in the severity of sinus headache and sinus pain, reported Dr. Chantal Tremblay, with Novabyss, Inc, of Sherbrooke, Quebec, Canada. Novabyss conducted the trial on behalf of Abbott Laboratories, the pharmaceutical company based in Abbott Park, IL, which manufactures clarithromycin. There was also a trend towards improvement in nasal congestion, nasal discharge and quality of discharge. Treatment-related side effects included diarrhea, taste perversion and nausea, all of which are typically associated with clarithromycin. No patients dropped out of the study because of side effects due to treatment. The authors say their study demonstrates that clarithromycin's anti-inflammatory effects are beneficial in patients with a persistent inflammatory reaction in respiratory tissues such as sinus mucosa. Elsewhere at the meeting, researchers also reported that an Abbott ketolide compound in development, known as ABT-773, shows excellent antimicrobial activity against selected strains of Staphylococcus pneumoniae. E-mail this page to a friend or colleague! To print, use this version