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DG DISPATCH - AACAP: Risperidone May Treat Aggression In Youths By Lara Pullen Special to DG News CHICAGO, IL -- October 27, 1999 -- An increasing amount of research is being done on the treatment of bipolar disorder in children and adolescents. A recent study indicates that risperidone might be useful in the treatment of aggression in youths with bipolar disorder. At the 46th annual meeting of the American Academy of Child and Adolescent Psychiatry, Dr. Jean A. Frazier, of Massachusetts General Hospital, in Boston, presented the results of a recently completed treatment study of juvenile bipolar disorder. The study examined the effects of risperidone, an atypical antipsychotic, which has had mixed results in the treatment of adults with bipolar disorder. The study was a retrospective chart review designed to address the psychopharmacology of aggression. The 28 children in the study had bipolar disorder and were being treated with risperidone (2.5 - 20 mg/day) in an academic setting. The results showed significant improvement in symptoms of mania (82 percent), psychosis (69 percent) and aggression (82 percent). The side effects included weight gain and sedation. Dr. Frazier said that the results of this study and others show that atypical antipsychotics hold much promise in the long-term treatment of high psychosis and bipolar disorder in children. She recommends further studies to look at the effect of these drugs on cognition as preliminary data suggest they may actually improve cognition. E-mail this page to a friend or colleague! To print, use this version