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Gastroesophageal Reflux Disease Not Related To H. Pylori CHICAGO, IL - July 14, 1999 -- Helicobacter pylori plays no role in the pathogenesis of gastroesophageal reflux disease or its complications, according to an article in this month’s issue of Archives of Surgery. The researchers studied 229 patients with symptoms such as heartburn, trouble swallowing and epigastic pain, to determine if there was any association between gastroesophageal reflux disease and the presence of H. pylori. For more than 15 years, H. pylori has been accepted as an important factor in the development of duodenal ulcer and distal gastric cancer. "This study demonstrates that H. pylori plays no role in the pathogenesis of gastroesophageal reflux disease or its complications," the authors write. "We found no difference in the median time of esophageal acid exposure or the prevalence of abnormal esophageal acid exposure, erosive esophagitis and Barrett esophagus in patients with and without H. pylori." The authors recommend further investigation to determine if certain strains of H pylori protect against the complications of gastroesophageal reflux disease. E-mail this page to a friend or colleague! To print, use this version