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DG DISPATCH -- INFLAMMATION: Oxidised LDL Linked To Disease Activity In Rheumatoid Arthritis By T.N. Brignol, MD Special to DG News PARIS, FRANCE -- June 29, 1999 -- Oxidised low density lipoprotein (LDL) may be involved in the pathogenesis of rheumatoid arthritis (RA) and may serve as an additional marker of disease activity, researchers report at the fourth World Congress on Inflammation in Paris, France. Dr. I.M.M. Laurindo, from the division of rheumatology, University of Sao Paulo School of Medicine, Sao Paolo, Brazil, said the researchers analysed the presence and degree of oxidative modifications of LDL in the synovial fluid (SF) and serum in 27 RA patients (six men, 21 women) (three years mean duration of symptoms). The mean age was 41 years (27-72). The control group included six patients (one man, five women) with osteoarthritis (19 months mean duration of symptoms). The mean age was 70 years (59-80). The researchers determined the presence of oxidative LDL in SF and serum with the ELISA test. The results show higher levels of oxidative LDL in SF and serum in the RA patients. High oxidative LDL levels in SF are associated with high level of oxidative LDL in serum. The researchers found a correlation between high levels of oxidative LDL and clinical signs of inflammatory activity. E-mail this page to a friend or colleague! To print, use this version