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DG DISPATCH - EULAR: Fosamax Increases Bone Mass In Men With Osteoporosis By David Jack Special to DG News GLASGOW, SCOTLAND -- June 10, 1999 -- Males have often been neglected as far as osteoporosis is concerned and few trials have been performed in male-only groups. The results of the first year of follow-up from a study looking at this population were presented yesterday by Dr. Johann Ringe, Medizinische Klinik 4, Klinikum Leverkusen, University of Cologne, Leverkusen, Germany, at the European League Against Rheumatism (EULAR) conference in Glasgow, Scotland. Dr. Ringe described his on-going prospective controlled trial comparing Merck’s Fosamax™ (alendronate) with alfacalcidol in 122 men with established osteoporosis (in the ALN group, there were 60 men mean age 52.4, in the alfacalcidol group there were 62 men mean age 53.4). Since established primary osteoporosis was the main inclusion criterion, there was no placebo control group. Patients were randomly allocated to either Fosamax 10 mg or alfacalcidol 1 mg. All patients in the study also received 500 mg calcium. The mean increase in lumbar spine bone mass density (BMD) after 12 months of treatment with Fosamax was 7.7 percent compared with 0.9 percent in the alfacalcidol group. In addition, there have been four vertebral and nine non-vertebral fractures in the Fosamax group versus 10 vertebral and 15 non-vertebral fractures in the alfacalcidol group. Both treatment regimens were well tolerated, Dr. Ringe said. The study is on-going and further results will be reported at a later date, according to the researcher. Related Links: Fosamax, Merck E-mail this page to a friend or colleague! To print, use this version