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DG DISPATCH - ECFC: Third-Generation Cephalosporins Linked To Bacteria Infection In CF Patients By Martin Goldman Special to DG News THE HAGUE, THE NETHERLANDS -- June 10, 1999 -- Third-generation cephalosporin antibiotics play a role in predisposing cystic fibrosis patients to Stenotrophomonas maltophilia colonisation and infection, according to new research presented at the European Cystic Fibrosis Congress (ECFC) in The Hague, The Netherlands. The data was presented by Dr. Celine Piegay of the Service d’Epidemiologie et Hygiene Hospitaliere, Dijon, France. Her study reported that previous S. aureus colonisation and recent use of antibiotics also seem to be factors in predisposing cystic fibrosis patients to S. maltophilia infection. Thirty-three cystic fibrosis patients were enrolled in the retrospective, multi-centre, case control study which aimed to identify predisposing factors. Other predictive factors identified in this study were mean number of days in hospital (4.5 days for infected versus 1.4 for controls) and duration of oral antibiotic therapy (50.7 versus 22.4). S. maltophilia is a ubiquitous organism, which has been increasingly identified as a significant pathogen in cystic fibrosis. When it occurs in addition to the more usual pathogens, such as Pseudomonas aeruginosa and Staphylococcus aureus, it seem to be directly related to the patients’ deterioration. Dr. Piegay suggested that physicians should consider the presence of these predisposing factors before prescribing third-generation cephalosporins in their cystic fibrosis patients. E-mail this page to a friend or colleague! To print, use this version