Unregistered User If this is not your name, click here.
		Contact Us | Order Now | Journals | Bookstore | Register a colleague
	Select a ChannelAcneAIDS and HIVAllergy OtherAlzheimer'sAnaesthesiology OtherAngina Pectoris/MIAnxietyArthritis OtherAsthmaBack PainBacterial InfectionsBladder CancerBone Marrow TransplantationBreast CancerCardiology OtherCataractCell TransplantationCervical CancerCholesterol/Lipid disordersCirrhosisClinical PharmacologyColorectal CancerCongestive Heart FailureContact DermatitisContraceptionCOPDCystic FibrosisDental and Oral DisordersDepressionDermatology OtherDiabetesDialysisEating DisordersElbowEmergency MedicineEndocrinology OtherEpilepsyErectile DysfunctionFibromyalgiaGastro OtherGeneticsGenitourinary OtherGeriatricsGERD/GastritisGlaucomaH. Pylori/UlcerHaematology OtherHair LossHeadachesHepa/Biliary OtherHepatitisHipHRTHypertensionIBDImmunologyInfectious OtherInfertilityIntensive CareIrritable Bowel SyndromeKneeLeukemiasLiver CancerLung CancerLupusLymphomasMelanomaMenopauseMultiple Sclerosis Nephrology OtherNeurologic OtherNutritional / Metabolic OtherOb/Gyn OtherObesityOncology OtherOphth. OtherOphthalmic SurgeryOrgan TransplantationOrthopaedics OtherOsteoarthritisOsteoporosisOtitisOtorhino. OtherOvarian CancerPaediatricsPainPancreatic CancerParkinson'sPregnancyProstate CancerPsychiatry OtherPulmonary OtherRadiologyRenal CancerRenal FailureRespiratory InfectionsRheumatoid arthritisRheumatology OtherRhinitisSchizophreniaShoulderSleep ApnoeaSleep DisordersSpineStrokeSTDsSurgeryThyroid DisordersTransfusionTransplant Surgery OtherTraumaUrinary IncontinenceUrinary tract infectionsVaccinologyVascular DisordersViral Infections

SEARCH   News Bookstore Medline The Web Meetings & Congresses Complete Doctor's Guide    EXPLORE :    All News   All Webcasts   All Cases   All Meetings & Congresses   All Medical Resources New drugs / indications English Dictionary Medical Dictionary Thesaurus Warning | Privacy | Awards  Favourite Journals  Click here to choose your favourite journals  Favourite Sites  Click here to choose your favourite sites  Languages  Select languageEnglishFrançais

DG DISPATCH - EULAR: Leflunomide Of Benefit In Active RA By David Jack Special to DG News GLASGOW, SCOTLAND -- June 9, 1999 -- Hoechst Marion Roussel’s leflunomide is more effective than methotrextate in improving health status measures and functional activities in patients with rheumatoid arthritis, according to the results of a study presented by Dr. P. Tugwell, from the University of Ottawa, and colleagues from the Leflunomide US Investigators Group. The results of their study were presented at a poster session yesterday during the European League Against Rheumatism (EULAR). Leflunomide is one of the new disease-modifying antirheumatic drugs. The 12-month, multi-centre, randomised, placebo-controlled trial compared the efficacy of leflunomide with methotrexate. A total of 482 patients were randomised to receive either leflunomide 20 mg daily after a 100 mg loading dose for three days, methotrexate 7.5 to 15.0 mg/weekly or placebo. A Modified Health Assessment Questionnaire was administered monthly, Problem Elicitation Technique and Medical Outcomes Survey Short Form 36 at baseline, 24 and 52 weeks. Mean changes in test scores showed a significant improvement in function and health related quality of life with leflunomide treatment compared with placebo. Many of the other parameters were also significantly improved. Leflunomide produced significantly greater improvements than methotrexate in the Modified Health Assessment Questionnaire, five of the eight Health Assessment Questionnaire Scales and Disability Index, weighted top five of Problem Elicitation Technique and two of eight subscores of the Medical Outcomes Survey Short Form 36. The researchers concluded that functional ability improved from baseline in both active treatment groups but that leflunomide produced a significantly greater improvement than methotrexate in health status measures and functional activities which are considered important for a patient’s health-related quality of life. E-mail this page to a friend or colleague! To print, use this version