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Ketorolac Tromethamine Does Not Reduce Pain, Discomfort Associated With Mammograms: Presented at SABCS By Jennifer Reising SAN ANTONIO, Tex -- December 16, 2009 -- Ketorolac tromethamine does not reduce the pain and discomfort experienced by patients during mammography, when compared with placebo, according to a study presented here at the 32nd Annual San Antonio Breast Cancer Symposium (SABCS). Researchers sought to study the possibility of reducing the pain and discomfort experienced during mammography, by means of using an analgesic as premedication. “There was no difference between the 2 arms of the trial, indicating that the use of ketorolac tromethamine has no benefit in reducing pain and discomfort for patients during a mammogram,” said Ruffo Freitas-Junior, MD, Goiás Anticancer Association, Goiânia, Goiás, Brazil, on December 12. The randomised, double-blind, placebo-controlled study included 308 patients. Of these, 153 patients (group 1) received 10 mg of ketorolac tromethamine orally and 155 (group 2) received placebo orally at 60 minutes before undergoing a mammographic examination. Patients filled out a form asking about personal data and possible factors relating to pain and discomfort while undergoing mammography. After the examination, the patients subjectively assessed the pain and discomfort experienced during the examination using a visual analogue scale (VAS) graded from 0 to 10. Results show that the mean VAS pain level presented by the patients was 3.36 and the median was 2.90. It was observed that 51 (16.6%) of the patients did not present any pain, 106 (34.4%) presented mild pain, 94 (30.5%) had moderate pain, 40 (13%) presented severe pain, and 17 (5.5%) had intolerable pain. With regard to discomfort, 68 (54.9%) reported tolerable discomfort, 63 (20.5%) had a lot of discomfort, and 8 (2.6%) reported intolerable discomfort. Among the factors related to pain, only the presence of previous mastalgia was significant (P < .05). The adverse event most present was somnolence, with 2.6% of patients in the ketorolac group and 5.8% in the placebo group reporting this condition. [Presentation title: Randomized Double-Blind Placebo-Controlled Clinical Trial Testing Ketorolac Tromethamine for Reducing the Pain and Discomfort Experienced During Mammography. Abstract 4014] E-mail this page to a friend or colleague! To print, use this version