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Chemoembolisation Improves Survival in Patients With Unresectable Liver Cancer RESTON, Va -- November 20, 2009 -- In patients with unresectable liver cancer, triple-drug transcatheter arterial chemoemobolisation (TACE) followed by a liver transplant may significantly increase a patient’s chance of long-term survival, according to a study published in the December issue of the American Journal of Roentgenology. The study, performed at the David Geffen University of California at Los Angeles (UCLA) School of Medicine, Los Angeles, California, included 124 patients with unresectable liver cancer. Of the patients, 28 patients underwent triple-drug TACE followed by a liver transplantation and 96 patients underwent triple-drug TACE only. “In our study, patients who underwent triple-drug TACE followed by liver transplantation showed the longest survival,” said lead author, Antoinette S. Gomes, MD, David Geffen UCLA School of Medicine. The median survival in the transplant recipient group was 112.80 months and 15.75 months in the group who did not receive a transplant. “Until recently, there has been considerable controversy regarding the benefits of emobolisation therapy in patients with unresectable liver cancer,” said Dr. Gomes. “In our series, survival after TACE was best in patients who ultimately underwent liver transplantation. However triple-drug TACE alone still improved survival in patients who did not undergo a liver transplantation,” she said. During triple-drug TACE, anti-cancer drugs are injected directly into the blood vessel feeding a cancerous tumour. An embolic agent is placed inside the blood vessels that supply blood to the tumour, in effect trapping the chemotherapy in the tumour. SOURCE: American Journal of Roentgenology E-mail this page to a friend or colleague! To print, use this version